ASLM’s Resource Center is designed to help you keep up with the latest tool kits, regulations, guides and other information published by ASLM, partners, and global health regulatory bodies. Use the filters above to locate the information you need based on the ASLM project, resource type, or topic of interest.
In this MEDSCAPE commentary, Dr Paul Sax from Brigham and Women’s Hospital and Harvard Medical School summarises some of the most common questions regarding COVID-19 and HIV: Is COVID-19 a more severe disease in people with HIV? Do I need to come in for my regular blood tests and checkups? Do my antiretroviral medications protect… Read More
In this guideline, specifically prepared for COVID-19 pandemic, Africa CDC advises Member States to use the characteristics of the epidemic in their country to decide when and how to do contact tracing. Namely, in Epidemic Phase 1-2 where imported cases and cases in known transmission chains the guidance is to trace all contacts. In Epidemic… Read More
The Writing Group of the Johns Hopkins University and Johns Hopkins Hospital COVID-19 Treatment Guidance Working Group presents a compressive guidance for existing treatment for COVID-19. The guidance strongly recommends clinical trials for potential treatments before any use, how to use immune modulatory agents to treat COVID-19 such as IL-6R or IL-6 Monoclonal antibodies, intravenous… Read More
This study by Nathan Ford, et al. (20 March, 2020), published in the Journal of the International AIDS Society, presents the systematic review of clinical outcomes using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. Their review indicates that it is uncertain whether LPV/r and other antiretrovirals improve clinical outcomes… Read More
On 20 May 2020, this COVID-19 ECHO session was convened to discuss procurement and the supply chain for COVID-19 diagnostics. Dr Lara Vojnov, Diagnostics Advisor at the World Health Organization, Geneva, and Dr Yenew Kebede, Head of Laboratory Services at Africa CDC presented about the need to coordinate and collaborate test availability and access; current… Read More
On 14 May 2020, this COVID-19 ECHO session was convened to assist the African laboratory community in designing and implementing an effective COVID-19 quality assured testing program. Mr Patrick Mateta, Vice President, Global Health Partnerships, at Clinical and Laboratory Standards Institute (CLSI) presented about how to plan and prepare for COVID-19 testing, the selection and… Read More
This article, published in STAT, lists the COVID-19 drugs and vaccines in development, to help inform efforts to treat or prevent COVID-19. Note: The article lists novel medicines, not repurposed medicines.
This is guidance from the World Health Organization on the use of masks during the COVID-19 pandemic in communities, during home care, and in healthcare settings. This guidance will inform healthcare workers, community workers, and infection and prevention experts as they fight the COVID-19.
LabCoP’s April ECHO session featured presentations about maintaining HIV and TB testing in the context of COVID-19 from Dr George Alemnji, Senior Technical Advisor for Laboratory Services at the State Department Office of Global AIDS Coordinator (SGAC) and Health Diplomacy, US CDC; Dr Lara Vojnov, Diagnostics Advisor, WHO; and Dr Dennis Falzon, Medical Officer, World… Read More
On 8 May 2020, ASLM hosted part 2 of an ECHO session about COVID-19 serology tests. Serological diagnostic testing has been proposed to be useful in combination with molecular testing, in confirming COVID-19 infection or exposure to the virus. Serology tests also have the potential to be delivered in rapid format and at the point… Read More
On 30 April 202, ASLM we host the third set of manufacturers of COVID-19 molecular diagnostic tools, featuring Abbott and Bio-Rad. Dr Danijela Lucic, Senior Scientific Affairs Manager, Global Infectious Disease, Abbott Molecular, and Dr Marcus Neusser, EMEA Product Manager, Gene Expression, Bio-Rad, Germany, and Mr Richie Petronis, Product Manager, Bio-Rad, USA, presented about their… Read More
On 29 April 2020, ASLM hosted this ECHO session on strategies to implement fast turn-around laboratory testing for control of COVID-19, presented by Dr Trevor Peter, Senior Director, Diagnostic Services, Clinton Health Access Initiative. Nucleic acid testing is the WHO-recommended method for detecting SARS-CoV-2. The global scale-up of COVID-19 diagnostics will depend on use of… Read More
On 24 April 2020, Professor Rosanna Peeling and colleagues from the International Diagnostics Centre at the London School of Hygiene and Tropical Medicine pulled together evidence for and against the original set of recommendations for use of serologic tests. Prof Peeling was joined by Dr Yenew Kebede from Africa CDC and Dr Amadou Sall from… Read More
On 16 April 2020, ASLM hosted the second set of manufacturers of COVID 19 molecular diagnostic tools. Dr Davide Manissero, Chief Medical Officer of Infection and Immune Diagnostics at QIAGEN, and Mr Riegardt Johnson, Field Application Scientist at Thermo Fisher Scientific presented about their available COVID-19 laboratory test kit(s), their status regarding regulatory approval, their… Read More
On 14 April 2020, ASLM hosted the first set of manufacturers of COVID-19 molecular diagnostics tools, including BD and Cepheid. Dr Charles Cooper, Global Vice President, Medical Affairs, Integrated Diagnostic Solutions at BD, and Ms Rujeko Tsomondo, Regional Application Lead at Cepheid presented about their available COVID-19 laboratory test kit(s), their status regarding regulatory approval,… Read More
This paper describes the steps taken by Brazil before the first COVID-19 cases were identified in that country. The steps included creation of ordinances and laws, setting up of emergency operating centers, and clearly articulating how isolation and quarantine will be done. The paper also examines the advantages of these measures. Based on the Brazilian… Read More
This paper highlights important research questions regarding SARS-CoV-2 which include origin, virus transmission, viral shedding, diagnosis, treatment, vaccine development and viral pathogenesis. The paper proposes that research on SARS-CoV-2 and COVID-19, if it seeks to answer these important questions, will solidify the scientific basis on which important policy and scientific decisions are made to contain… Read More
On 8 April 2020, ASLM and LabCoP convened a special ECHO session on lessons the African continent can learn from the Korean experience in controlling COVID-19 Dr Seon Kui Lee, Director, Division of Risk Assessment & International Cooperation at the Korea Centers for Disease Control and Prevention (KCDC), shared an overview of the KCDC and… Read More
On 30 March 2020, ASLM and LabCoP convened a special ECHO session on the latest available technology to diagnose COVID-19, and recommendations for clinical care and surveillance. Dr Cassandra Kelly-Cirino, from the Foundation for Innovative New Diagnostics (FIND), and Prof Rosanna Peeling, from the London School of Hygiene & Tropical Medicine, gave an overview of… Read More
On 25 March 2020, ASLM and LabCoP convened an ECHO session on troubleshooting common challenges associated with establishing diagnostic testing for SARS-CoV-2 (the causative agent of COVID-19). Dr Jinal Bhiman, Director of the National Influenza Centre at the NICD, South Africa, presented practical solutions to address the most common challenges encountered by laboratory staff recently… Read More
This presentation by Prof Yazdan Yazdanpanah, published by the Global Research and Innovation Forum, presents a global roadmap for the control of COVID-19. The roadmap defines research priorities regarding how to stop the transmission of COVID-19, and how to mitigate its impact, as well as a governance framework from an ethics point of view. The… Read More
This study, by Xi He et al, published in Nature Medicine (15 April, 2020), reports that 44% of secondary COVID-19 cases were transmitted by people who had not yet developed symptoms. The findings emphasize that control measures should be adjusted to account for probable substantial presymptomatic transmission. Sensitive and specific molecular and serological testing is… Read More
Laboratories need to conduct verification or validation studies to confirm that new tests for COVID-19 diagnosis perform as intended. In this document co-authored by ASLM, FIND and the London School for Hygiene and Tropical Medicine, further key requirements for quality assurance are defined, including quality control and external quality assurance that laboratories should follow to… Read More
This study by Dr Bin Cao, et al, 2020, in the New England Journal of Medicine describes a trial of lopinavir–ritonavir in adults hospitalised with severe COVID-19 where no benefit was observed with this treatment beyond standard care.
This systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS, or COVID-19 (initial assessment) was conducted by Dr Nathan Ford, et al, 2020. Their conclusion from the available evidence is that it is uncertain whether LPV/r and other antiretrovirals improve clinical outcomes or prevent infection among patients at high risk of… Read More
This report details the first full genome sequence of SARS-CoV-2 from Africa to be released, with genomic data generated and assembled, and phylogenetic analysis performed by ACEGID and NIMR scientists.
The Liverpool Drug Interactions Group (based at the University of Liverpool, UK), presents an exhaustive chart about common drug interactions with experimental COVID-19 therapies.
This March 2020 presentation of the WHO-China joint mission includes key findings on COVID-19. Epidemiologic and technical insights to contain the pandemic are also covered.
This modelling study by Marius Gilbert, et al, published in the Lancet, 2020, evaluates preparedness and vulnerability of African countries against importations of COVID-19. Their evaluation was based on WHO International Health Regulations (IHR) Monitoring and Evaluation Framework (MEF), and on an indicator of vulnerability to emerging epidemics.
This article published in the New England Journal of Medicine by W. Guan, et al, 2020, describes the clinical characteristics of affected patients with COVID-19 in China. The findings show more frequent absence of fever in COVID-19 than in SARS-CoV (1%) and MERS-CoV infection (2%). This can have an implication if surveillance case definition focuses… Read More
This paper published in the New England Journal of Medicine by Neeltje van Doremalen, et al, 2020, describes the stability of viable SARS-CoV-2 on surfaces and in aerosols in comparison with SARS CoV-1. The results indicate that aerosol and fomite transmission of SARS-CoV-2 is plausible, as the virus can remain viable in aerosols for multiple… Read More
This article by Mark S. Lesney and published by MDedge, 2020, highlights the news that researchers have identified the structure of a spike protein that could turn out to be a potential vaccine target for the 2019-nCoV that causes COVID-19. The research further suggests that future antibody isolation and therapeutic design efforts will benefit from… Read More
This report by WHO gives an overview on the use of licensed medicines for indications that have not been approved by regulatory authorities. It provides a scientific summary of key aspects to consider in off label use of medicines and the need to adhere to national regulations on the use of medicines. It also stipulates… Read More
This is an exhaustive PowerPoint presentation by Paolo Surico and Andrea Galeotti about the economics of a pandemic, using COVID-19 as a case study. The presentation sheds light on the science, health policies, economics and macroeconomic policies.
The European Centres for Disease Prevention and Control (ECDC) has published this technical report about safe handling of bodies of deceased persons with suspected or confirmed COVID-19 to be used by public health authorities in EU/EEA Member States and the United Kingdom. These considerations may help inform the approach in Africa.
This paper by Erin K. McCreary and Jason M. Pogue about COVID-19 treatment describes a review of early and emerging options. The authors summarize the current evidence as of 19 March 2020 to provide guidance on potential COVID-19 treatment options.
The Nigeria Centre for Disease Control published this self-isolation guidance for Nigerians on 18 March 2020 that providesdetailed description of what self-isolation means during COVID-19 pandemic and step-by-step instructions for adherence. This guidance may help inform the policies set forth my ministries of health of other African countries.
This paper by Chengzhi Yang & Zening Jin, 2020, indicated that individuals with underlying chronic cardiovascular diseases (CVDs) were both more susceptible to COVID-19 and more prone to critical conditions and death. Therefore, continued observations of the cardiovascular complications of the disease are needed.
This paper by Shaobo Shi et al, 2020, explores the association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China.
Africa CDC has published this guidance and recommendations for community social distancing during the COVID-19 outbreak. Social distancing is an accepted strategy to delay and reduce the magnitude of outbreaks of pandemic influenza. It is necessary at the individual and community levels, because transmission occurs frequently from person-to-person.
This paper by David M. Morens and Anthony S. Fauci provides insight about the 1918 influenza pandemic and lessons learned, which could still apply in the 21st Century related to COVID-19, Ebola or other outbreaks.
This review about the epidemiology and pathogenesis of coronavirus disease (COVID-19) by Hussin A. Rothan et al, 2020, in the Journal of Autoimmunity highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis, and future directions to control the spread of this fatal disease.
This paper by Yixuan Wang et al, 2020 summarises the latest literature on genetic, epidemiological, and clinical features of COVID-19 compared to SARS and MERS, and emphasises special measures on diagnosis and potential interventions. This review can improve our understanding of the unique features of COVID-19 and enhance our control measures in the future.
WHO has published an interim operational guide for maintaining essential health services during an outbreak, to support countries preparedness and response during the COVID-19 outbreak. It supplements existing and future WHO guidance on the wider implications of COVID-19 for health systems, and cross-government strategies for responding to the COVID-19 outbreak.
WHO has published interim guidance for laboratory testing for coronavirus disease COVID-19 in suspected human cases. It also describes safety procedures for specimen collection and testing from suspected cases and contacts. Suspect cases should be screened for the virus with nucleic acid amplification tests (NAAT), such as RT-PCR. Download the guide and read more.
WHO has published these recommendations for health workers and global health professionals who travel, to help them stay safe and minimise their chances of contracting the 2019-nCoV in the course of their work. Please download these documents below.