This session, organized in collaboration with Cepheid, brought together TB diagnostics experts to discuss the effective use of Xpert MTB/RIF Ultra and Xpert MTB/XDR within national TB diagnostic networks. It focused on practical ways to strengthen testing workflows, improve result interpretation, reduce unsuccessful tests, and support the timely detection of TB and drug resistance. Dipti Lallubhai, Senior Manager, Cepheid Medical and Scientific Affairs, and Nqobile Ngoma, Clinical Epidemiologist and Senior Clinical Solutions Executive, Cepheid, addressed questions raised during previous LabCoP exchanges, including test sensitivity, reflex testing approaches, and interpreting results for clinical and programmatic decision-making. Abdunoor Nyombi from Uganda NTRL shared implementation experience and practical lessons on the placement of Xpert MTB/RIF Ultra and Xpert MTB/XDR in diagnostic algorithms and impact on program outcomes. Session materials, including the recording, presentations, resources, and related publications, are available through the links below.