The recent US government stop work order has the potential to negate the gains in the global health space including HIV response towards achieving global targets for viral suppression, averting new infections and deaths unless governments take meaningful steps to continue funding these initiatives. In this session, presented by Prof. Francois Venter, Executive Director, Wits Ezintsha at the Faculty of Health Sciences, University of Witwatersrand Johannesburg, we cover the history of PEPFAR, the devastating impact of the immediate funding freeze in Africa, and the anticipated effects on social, economic, and health programs. In addition, we discuss national-level potential mitigating strategies for both the short and long term. Please follow the links here to view the recorded ECHO session and download presentation slides.