On 10 September 2020 LabCoP hosted a special ECHO session about establishing diagnostic connectivity for laboratory network data flow across conventional and point-of-care systems. More than before, use of clinical laboratory data to inform decision making has become crucial in both direct patient care and in local, regional and international healthcare systems programming. The emergence of the COVID-19 pandemic has further highlighted the critical need to have rapid and robust mechanisms to collect, store, transmit, and analyse laboratory data for the generation of necessary information to guide the global response of the outbreak. In this resource, we explore the role of data management through connectivity from peripheral service points to regional and national data management centers via available information and technology platforms. Uganda and Mozambique discussed how their laboratory information systems continued to revolutionise and improve patient care. Presentations were made by Proscovia Nambuya Mbabazi, Head of Information and Technology, Department of Health Diagnostics and Laboratory Services, Ministry of Health-Uganda, and Chishamiso Mudenyanga, Program Manager, Clinton Health Access Initiative, Mozambique. Please follow the links posted here to view the recorded video session on ASLM’s YouTube channel, and download the presentation slides from the session.