LabCoP’s Waste Management Sub CoP ECHO session, held on 18 July 2024, focused on Handling Large Volume Molecular Liquid Waste Containing Guanidine Thiocyanate and pilot studies from Nigeria and Uganda. Given the scale up of viral load (VL) testing and early infant diagnosis (EID) of HIV globally over the last decade, there has been a substantial increase in the quantities of solid, liquid, and gaseous chemical and infectious wastes at testing laboratories and healthcare facilities. Molecular liquid waste (MLW) generated from these test procedures generally contain guanidine thiocyanate (GTC), a chemical known to be toxic to humans, animals and the ecosystem if not properly handled and disposed of. There are approaches, including advanced oxidation, with the potential to render cyanide in the GTC non-hazardous. Presentations are made by Mr Joel Peter Opio, Public Health Specialist at the United Stated Centers for Disease Control and Prevention (US CDC) Uganda; and Dr Ughweroghene Kingston Omo-Emmanuel, Clinical Laboratory Program Manager with United States Agency for International Development (USAID) Nigeria. They investigate Uganda’s use of Hydrogen Peroxide (H2O2) and ultraviolet light in the treatment of liquid waste from molecular laboratories, and Nigeria’s experience running a centralized incineration facility for molecular liquid waste. Please follow the links here to view the recorded ECHO session and download presentation slides.