Dolutegravir vs. Efavirenz in Women Starting HIV Therapy in Late Pregnancy (DolPHIN-2)
In this paper, Kenneth Kintu, et al, investigated the virological suppression (achieving viral loads < 50 copies per mL) before giving birth with dolutegravir compared to efavir
Management of Severe COVID-19
David Berlin, et al, present key clinical features of severe COVID-19 in the New England Journal of Medicine (21 May 2020). The authors start with a clinical description of a 50-ye
A Human Monoclonal Antibody Blocking SARS-CoV-2 Infection
In Nature Communications, Chuyan Wang, et al (4 May, 2020) describe a human monoclonal antibody that neutralizes SARS-CoV-2 in cell culture. The authors highlight that the cross-ne
Clinical Outcomes of Hydroxychloroquine in Hospitalized Patients with COVID-19
In a retrospective study of hospitalized patients with COVID-19, by Joshua Barbosa et al, published in the New England Journal of Medicine, it shows that Hydroxychloroquine does no
Systematic Review of the Efficacy and Safety of Antiretroviral Drugs Against SARS, MERS or COVID-19: initial assessment
This study by Nathan Ford, et al. (20 March, 2020), published in the Journal of the International AIDS Society, presents the systematic review of clinical outcomes using antiretrov
Updated Guide to the Coronavirus Drugs and Vaccines in Development
This article, published in STAT, lists the COVID-19 drugs and vaccines in development, to help inform efforts to treat or prevent COVID-19. Note: The article lists novel medicines,
The Brazilian response to COVID-19
This paper describes the steps taken by Brazil before the first COVID-19 cases were identified in that country. The steps included creation of ordinances and laws, setting up of em
SARS-CoV-2 and COVID-19: The Most Important Research Questions
This paper highlights important research questions regarding SARS-CoV-2 which include origin, virus transmission, viral shedding, diagnosis, treatment, vaccine development and vira
Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19
This study, by Xi He et al, published in Nature Medicine (15 April, 2020), reports that 44% of secondary COVID-19 cases were transmitted by people who had not yet developed symptom
Trial of Lopinavir–Ritonavir in Adults Hospitalised with Severe COVID-19
This study by Dr Bin Cao, et al, 2020, in the New England Journal of Medicine describes a trial of lopinavir–ritonavir in adults hospitalised with severe COVID-19 where no benefi