Reconstructing Laboratory Systems: How to Rebuild in Ebola-Affected Countries

Reconstructing Laboratory Systems: How to Rebuild in Ebola-Affected Countries

Pres. Sirleaf, Liberia
Pres. Sirleaf, Liberia
As the world’s most devastating Ebola epidemic draws to a close, governments and local institutions are looking to the future. Emerging from the urgent task of crisis management, experts are asking what steps can be taken to rebuild badly shaken health infrastructures. In the words of Liberian president Ellen Johnson-Sirleaf, the tasks are now to “stamp out the last embers of this epidemic, transition toward restoration of health services and rebuild our health system in a resilient manner.” [1]

The Ebola epidemic exposed, and was fuelled by, a number of weaknesses in the health systems of affected countries. In many cases, governments were already aware of these issues and planning solutions. In the aftermath of the epidemic, the time to address these problems is now. Medical and diagnostic laboratories play a central role in an emerging vision of rebuilding resilient health systems in Guinea, Liberia and Sierra Leone.

National leadership has been at the forefront of efforts to rebuild; the governments of Guinea, Liberia and Sierra Leone made public their plans for recovery at the International Ebola Recovery Conference in July of 2015.

Management and surveillance

The delay between the emergence of cases of Ebola virus disease and the start of national containment efforts reflected a shortage of diagnostic laboratories and a lack of surveillance and reporting structures at the national and regional levels. The lack of any surveillance system, either local or integrated between countries, contributed to the escalation of what initially seemed to be a containable outbreak. [2] Intensive investment in laboratory testing, contact tracing and screening was crucial for establishing control over the epidemic.

In its wake, establishing a sustainable programme of integrated disease surveillance and response (IDSR) is a priority for the prevention of Ebola re-emergence. IDSR is a flexible system that can be used to monitor and control the spread of other infectious diseases prone to outbreak. As national officials and international partners build IDSR systems, they are also prioritising international communication about emerging threats and coordinated responses.

The need for more flexible, multi-pathogen approaches to infectious disease surveillance is a theme that has emerged from reflections on how best to rebuild. Earlier efforts at health development focused on individual diseases one at a time. While working towards the UN’s Millennium Development Goals, which focus on control of HIV/AIDS, malaria and tuberculosis, international partners had developed numerous parallel structures for disease-specific diagnosis and treatment. Unfortunately, the multitude of initiatives may have undermined more broadly-focused national institutions that could have helped coordinate local and national resources for a more comprehensive response. [3] [4]

Recovery efforts in collaboration with international partners are being framed in order to support, rather than undermine, district level health systems with national ownership. For example, Sierra Leone’s Ministry of Health and Sanitation has rolled out a health sector Service Level Agreement for all partnerships moving forward, to coordinate and monitor the activity of many partners within the Ministry of Health and Sanitation. Likewise, the Liberian redevelopment plan notes that being able to manage contractors is a useful skill learned in the course of the outbreak. [5]

In the transition from outbreak response to outbreak recovery, there will need to be an emphasis on improving the standards in peripheral laboratories in addition to regional facilities. Candace Eastman, CEO of Africabio Enterprises (AEI Global) in Liberia, notes that specific issues that will need to be addressed include accessibility, facility requirements to meet operational standards, inventory management, training, guidelines for consistency between laboratories, and a robust referral system. Robust national systems with wider capabilities will be better able to weather the shock of unexpected emerging infectious diseases in the future.

Supplies and Infrastructure

When the outbreak began, already-stretched laboratories faced even greater challenges. When adequate personal protective equipment (PPE) and reagents were needed most, the fragility of the supply chain became apparent. The danger of laboratory infection was tragically realised at the Kenema Government Hospital’s Lassa Fever research laboratory, which was shut down in August 2014. [6]

Sall_EbolareconstructionAs implementing partners conclude their clinical and diagnostic work, the equipment and supplies they have provided and facilities they have helped to build have the potential to become assets in a new, stronger health system. [7] A first step, notes Dr. Amadou Sall of the Institut Pasteur in Dakar, will be to determine what equipment exists and where it can be used most appropriately. “Making sure new things are working and being used properly is a line of action people need to be working on,” says Dr. Sall, adding that maintenance for these assets will be key to building them into a sustainable national laboratory system.

Biosafety concerns will also play a key role in strengthening laboratory infrastructure and supply chain. During the outbreak, the system showed gaps in biosafety training, pathways and procedures for collection and transport of post mortem samples, and a lack of PPEs and other biosafety measures in the laboratory. Ms. Eastman also acknowledges the importance of including private laboratories in biosafety strengthening efforts, stating that, “the private sector must be included in programmes to improve biosafety in order to ensure a continued public health response owned by all.”


Efforts to rebuild and strengthen laboratory systems will have considerable expense. Ms. Eastman knows that governments will not be able to be responsible for the necessary financial investments alone. “We need to start to think creatively,” she states. She mentions public-private partnerships as a possible solution. These partnerships will be inclusive of all entities that have the expertise to bring about change, and can provide measurable results. All collaborative efforts, however, will be guided by local legislation and policy to ensure an environment of quality and standards in the delivery of healthcare services both publicly and privately.

Human Resources

To build a robust system with broad capabilities, a talented and well-trained workforce is key. Before the outbreak began, health systems in each of the three countries had been compromised by long periods of civic unrest, which had taken a toll on human resources and health funding. Of a cadre of intermittently paid health system personnel, most were clinical, with few laboratory or public health workers, and no formal public health training programmes available. [8]

Concentration of health administration at the central level, with limited district or provincial level oversight, had led to inefficiencies in hiring and payment, along with slow communication between central authorities and local laboratories. Decentralising health administration is a priority for both more responsive surveillance systems and better human resources management. During the epidemic, the United Nations Development Programme (UNDP) coordinated salary payments for the doctors, nurses and laboratory staff in the path of the disease. [9] As the crisis wanes and each country re-establishes its own health system, building a sustainable payment system is a priority.

In Guinea, efforts are also underway to harmonise salaries between the national health system and other organisations.11 During the outbreak in Liberia, technicians abandoned laboratories all over the country following the death of six laboratory workers. Africabio Enterprises was the first to provide biosafety training to 25 laboratory technicians who had chosen to assist in the crisis when their colleagues abandoned the laboratory.

The training allowed the technicians to renew their confidence in their ability to carry out work safely, and provided an opportunity to share knowledge on working in a crisis. This lesson is an important one for future laboratory workforce development,highlighting the need to build a culture where technicians know their lives are valued, and are empowered to confidently interpret results and solve problems.

Eastman_EbolareconstructionDr. Sall says that the Ebola response effort has developed a core group of people who, having worked through the crisis, have expertise in detecting Ebola, and who can serve as the foundation from which a robust laboratory workforce is built. In the wake of the economic damage the epidemic caused, this need for personnel is a promising avenue for socio-economic recovery. Ms. Eastman also feels that this workforce can be a powerful actor in country-led recovery efforts, stating, “Physicians, researchers, and allied professionals must begin to lead by example. It isn’t only their plight, it goes beyond borders and resources-limited countries. We all know diseases have no boundaries in global health security.”


Media contact: Corey White, Senior Communications Officer (

Originally published in the October 2015 issue of Lab Culture newsletter.

By: Laurel Oldach (Editorial Team); Contributors: Amadou Sall, PhD (Institut Pasteur, Dakar), Candace Eastman (Africabio Enterprises, Inc.); Editors: Michele Merkel, MS (Editorial Team), Rosalie Whedbee, MPH (Editorial Team), Corey White, MPA (ASLM)

[1] Ellen Johnson-Sirleaf, foreword to Investment Plan for Building a Resilient Health System in Liberia, 2015-2021.

[2] Bausch D. The year that Ebola virus took over West Africa: Missed opportunities for prevention. Am J Trop Med Hyg 92(2), 2015.

[3] UNDP. “Recovering from the Ebola crisis”. 2015.

[4] Abramowitz. How the Liberian health sector became a vector for Ebola. Cult. Anthropol. Online (Fieldsights – Hot Spots) (2014) Retrieved 21 September 2015 from

[5] Investment Plan for Building a Resilient Health System in Liberia, 2015-2021.

[6] Chen ZL, Chang GH, Zhang WY, Chen Y, Wang XS, Yang RF, Liu C. Mobile laboratory in Sierra Leone during outbreak of Ebola: practices and implications. Sci China Life Sci, 2015, doi: 10.1007/s11427-015-4912-6.

[7] Goodfellow, Reusken and Koopmans. Laboratory support during and after the Ebola virus endgame: towards a sustained laboratory infrastructure. Euro Surveill. 2015; 20(12).

[8] Bausch D. The year that Ebola virus took over West Africa: Missed opportunities for prevention. Am J Trop Med Hyg. 2015 92(2).

[9] Getting Beyond Zero: UNDP Ebola ERR Support Framework.

[10] Getting Beyond Zero: UNDP Ebola ERR Support Framework.