ASLM’s Resource Center is designed to help you keep up with the latest tool kits, regulations, guides and other information published by ASLM, partners, and global health regulatory bodies. Use the filters above to locate the information you need based on the ASLM project, resource type, or topic of interest.
Low- and middle-income countries (LMIC) currently experience low testing coverage in the face of increasing demand to meet the needs of millions of people living with HIV, TB, HPV, hepatitis and other diseases. Therefore, innovative solutions are urgently needed to enable a robust, efficiently utilised testing capacity, and a healthy and secure market with competitive… Read More
This presentation by the Clinton Health Access Initiative outlines the steps of an integration implementation framework for tuberculosis (TB) and HIV diagnostics, and related diseases, top tips and caveats (what could go wrong and lessons learned) from pilot countries on each step and area of implementation. It provides a deeper understanding of activities required for… Read More
This presentation by the Clinton Health Access Initiative outlines the need for point-of-care (POC) testing, how integrated testing improves access to POC, the benefits of integration, and considerations and implementation framework for integrated testing.
The GX Capacity Utilisation Analysis Tool is an Excel-based tool to assess the capacity utilisation of GeneXpert platforms for integrating tuberculosis (TB), HIV, HCV and HPV testing. It has been used to identify platforms running with full-capacity and with un-used capacity to inform integration decisions in Cameroon, Ethiopia, Indonesia, Malawi, Nigeria, Tanzania, Uganda, Zambia, and… Read More
The Integration Readiness Assessment Tool is a checklist to evaluate and help select the sites in a country where tuberculosis (TB)/HIV/HCV/HPV integration on the GeneXpert platform would be most feasible.
ASLM and Foundation for Innovative New Diagnostics (FIND) have produced a guide on how to develop and validate in-house RT-PCR tests for SARS-CoV-2. This guidance is essential, particularly in settings with limited diagnostics, including low- and middle-income countries (LMIC) where diagnostics are not immediately available during a pandemic. During the current COVID-19 pandemic the much… Read More
ASLM in collaboration with the Africa Centres for Disease Control and Prevention, and in partnership with the Clinton Health Access Initiative, Amref and Last Mile Health present the Quality Assurance Framework for SARS-CoV-2 Antigen Rapid Testing for Diagnosis of COVID-19. This framework aims to provide general technical guidance to African Union Members States on the… Read More
On 10 September 2020 LabCoP hosted a special ECHO session about establishing diagnostic connectivity for laboratory network data flow across conventional and point-of-care systems. More than before, use of clinical laboratory data to inform decision making has become crucial in both direct patient care and in local, regional and international healthcare systems programming. The emergence… Read More
On 13 August 2020, this COVID-19 ECHO session was convened to discuss optimised diagnostic networks key role in responding to COVID-19. Optimised national diagnostic networks are key to increasing access to high-quality diagnostics. With the outbreak of the COVID-19 pandemic, some sub-Saharan African countries leveraged more than a decade of investments in strengthening and optimising… Read More
On 6 August 2020, this COVID-19 ECHO session was convened to discuss laboratory data management considerations for COVID-19 response. Long turnaround times (TAT) for laboratory test results and poor data quality are chronic problems for many testing services. Timely and accurate testing services for COVID-19 are essential for monitoring the spread of the pandemic and… Read More
On 15 July 2020, this COVID-19 ECHO session was convened to discuss the public health lab networks and SARS-CoV-2 testing challenges, strategies, and lessons learned from the USA. During emergencies like COVID-19 when laboratory testing services surge, there are risks of a health care system being overwhelmed. Well-structured strategies must be formulated to cope with… Read More
On 8 July 2020, ASLM hosted the seventh session in a series about manufacturers of COVID-19 molecular diagnostic tools, featuring EUROIMMUN AG, and Hologic. The session covers: overview of available SARS-CoV-2 laboratory test kit(s) e.g., what genes are targeted; performance, run time and other technical considerations of SARS-CoV-2 molecular diagnostics; requirements/consumables not supplied with the… Read More
On 18 June 2020, ASLM hosted the sixth session in a series about manufacturers of COVID-19 molecular diagnostic tools, featuring PerkinElmer and Pro-Med. Stephanie Wilbraham, Market Development Manager, PerkinElmer, and Neil Barker, Co-Founder, Pro-Med Diagnostics, South Africa presented about the overview of their available SARS-CoV-2 laboratory test kit(s), performance, run time & other technical considerations… Read More
On 2 June 2020, this COVID-19 ECHO session was convened to discuss establishing an integrated specimen referral system (SRS) for SARS-CoV-2 testing recommended to enable access to testing services across the entire health pyramid. Many countries struggled to operationalise this guidance and failed to create sustainable and efficient sample transportation systems. Due to various challenges,… Read More
In July of 2019, the World Health Organization and the African Society for Laboratory Medicine organized a meeting with countries and key stakeholders in diagnostics to discuss and find concrete ways to improve and increase access to integrated multiplex technologies and determine how they can be translated into public health policy that impacts global impact.
On 28 May, 2020 ASLM hosted the fourth session in a series about manufacturers of COVID-19 molecular diagnostic tools, featuring Abbott. Presentations were made by Dr Claudio Galli, Associate Director, Medical Scientific Affairs Global, Abbott Core Laboratory, and Dr Liane Bauer, Director, Professional Services EMEA, Abbott Core Laboratory. They covered topics including detection of COVID-19… Read More
On 20 May 2020, this COVID-19 ECHO session was convened to discuss procurement and the supply chain for COVID-19 diagnostics. Dr Lara Vojnov, Diagnostics Advisor at the World Health Organization, Geneva, and Dr Yenew Kebede, Head of Laboratory Services at Africa CDC presented about the need to coordinate and collaborate test availability and access; current… Read More
The May 2020 Waste Management training session focused on SARS-CoV-2 laboratory biosafety guidance and featured the presentation of David Bressler, Health Scientist and Microbiologist at the International Laboratory Branch of the U.S. Centers for Disease Control and Prevention. Nearly all countries are scaling up COVID-19 testing as one of the main strategies to eliminate the… Read More
On 14 May 2020, this COVID-19 ECHO session was convened to assist the African laboratory community in designing and implementing an effective COVID-19 quality assured testing program. Mr Patrick Mateta, Vice President, Global Health Partnerships, at Clinical and Laboratory Standards Institute (CLSI) presented about how to plan and prepare for COVID-19 testing, the selection and… Read More
On 29 April 2020, ASLM hosted this ECHO session on strategies to implement fast turn-around laboratory testing for control of COVID-19, presented by Dr Trevor Peter, Senior Director, Diagnostic Services, Clinton Health Access Initiative. Nucleic acid testing is the WHO-recommended method for detecting SARS-CoV-2. The global scale-up of COVID-19 diagnostics will depend on use of… Read More
On 24 April 2020, Professor Rosanna Peeling and colleagues from the International Diagnostics Centre at the London School of Hygiene and Tropical Medicine pulled together evidence for and against the original set of recommendations for use of serologic tests. Prof Peeling was joined by Dr Yenew Kebede from Africa CDC and Dr Amadou Sall from… Read More
Laboratories need to conduct verification or validation studies to confirm that new tests for COVID-19 diagnosis perform as intended. In this document co-authored by ASLM, FIND and the London School for Hygiene and Tropical Medicine, further key requirements for quality assurance are defined, including quality control and external quality assessment that laboratories should follow to… Read More
LabCoP’s April ECHO session featured presentations about maintaining HIV and TB testing in the context of COVID-19 from Dr George Alemnji, Senior Technical Advisor for Laboratory Services at the State Department Office of Global AIDS Coordinator (SGAC) and Health Diplomacy, US CDC; Dr Lara Vojnov, Diagnostics Advisor, WHO; and Dr Dennis Falzon, Medical Officer, World… Read More
On 16 April 2020, ASLM hosted the second session in a series about manufacturers of COVID-19 molecular diagnostic tools. Dr Davide Manissero, Chief Medical Officer of Infection and Immune Diagnostics at QIAGEN, and Mr Riegardt Johnson, Field Application Scientist at Thermo Fisher Scientific presented about their available COVID-19 laboratory test kit(s), their status regarding regulatory… Read More
On 14 April 2020, ASLM hosted the first session in a series about manufacturers of COVID-19 molecular diagnostics tools, including BD and Cepheid. Dr Charles Cooper, Global Vice President, Medical Affairs, Integrated Diagnostic Solutions at BD, and Ms Rujeko Tsomondo, Regional Application Lead at Cepheid presented about their available COVID-19 laboratory test kit(s), their status… Read More
On 8 April 2020, ASLM and LabCoP convened a special ECHO session on lessons the African continent can learn from the Korean experience in controlling COVID-19 Dr Seon Kui Lee, Director, Division of Risk Assessment & International Cooperation at the Korea Centers for Disease Control and Prevention (KCDC), shared an overview of the KCDC and… Read More
Mozambique provided this Excel-based tool, with its accompanying instructions, as a country example of a comprehensive diagnostic network optimization or mapping tool at the July 2019 Global Diagnostics Integration meeting in Geneva. The government sought a tool that could be: subnational, consider multiple potential technologies as well as both laboratory-based and point-of-care, incorporate testing across… Read More
Developed by the Clinton Health Access Initiative (CHAI) for its country teams and ministries of health, this tool can be used to assess the financial benefits of integrating tuberculosis (TB), HIV, and HCV testing on the GeneXpert machine. The tool only covers cross-cutting costs (i.e. not disease-specific) regarding the use of GeneXpert, such as equipment,… Read More
This paper by Yixuan Wang et al, 2020 summarises the latest literature on genetic, epidemiological, and clinical features of COVID-19 compared to SARS and MERS, and emphasises special measures on diagnosis and potential interventions. This review can improve our understanding of the unique features of COVID-19 and enhance our control measures in the future.
WHO has published interim guidance for laboratory testing for coronavirus disease COVID-19 in suspected human cases. It also describes safety procedures for specimen collection and testing from suspected cases and contacts. Suspect cases should be screened for the virus with nucleic acid amplification tests (NAAT), such as RT-PCR. Download the guide and read more.
The March 2020 waste management training session focused on Hologic’s Best Practices for Waste Handling. Todd Richmond of Hologic, shared his experiences, expertise and advice on the waste and contamination management of Hologic’s Panther. In collaboration with the African Society for Laboratory Medicine (ASLM) and the LabCoP community, the CDC International Laboratory Branch (ILB) offers… Read More
Pre-analytical challenges threaten the quality of viral load (VL) testing. This study determined the impact of delayed testing and warmer storage conditions on HIV RNA stability in diagnostic samples. Viral load in samples stored for up to a week reliably differentiated between patients with antiretroviral therapy (ART) suppression and ART failure in the majority of… Read More
Plasma preparation tubes (PPT) can simplify storage, transport, and preparation of plasma used for viral load (VL) testing. This systematic review evaluated the accuracy of PPTs for HIV VL testing. The results showed that following proper sample handling techniques helps provide accurate results. The authors thus recommended PPTs as a high-quality alternative specimen type for… Read More
In this session, colleagues from Kenya shared findings from the assessment of waste handling practices in their viral load (VL) and Early infant diagnosis (EID) laboratories. They discussed contextual issues in regard to VL & EID laboratory testing capacity and networks, laboratory self-assessment using a VL & EID customized assessment checklist, findings/results, lessons learnt, challenges… Read More
To reach the third 90 of the UNAIDS 90–90–90 targets, country programmes must delve into their data and understand how they represent the quality of viral load (VL) testing services. This guide, published by WHO, presents key considerations and examples of tools (provided in the annexes) to assist countries in developing a national VL M&E… Read More
The November 2019 Waste Management training session focused on the perspectives of Abbott Laboratories’ Best Practices for Waste Handling. Delfin Rubin, Global Product Manager of HIV Care for Infectious Disease Emerging Markets at Abbott Rapid Diagnostics, and Ami Soni, EHS Lead for Abbott Molecular describe the constituents of their HIV rapid point-of-care diagnostics, such as… Read More
The purpose of this tool is to assist in identifying gaps and creating awareness of best practices for waste management processes in viral load (VL) and early infant diagnosis (EID) molecular testing laboratories (and associated healthcare facilities), in order to provide a starting point for assistance in waste mitigation strategies. This tool is for completion… Read More
WHO has produced a biosafety video series entitled, “Good Microbiological Practice and Procedures (GMPP)”, which is central to the WHO Laboratory Biosafety Manual (LBM4) being revised and finalised. These seven training videos will help enhance the safety of any health laboratory, including those in resource-limited settings.
This fact sheet gives the situation as of July 2019 of the status of HIV self-testing (HIVST) in national policies, implementation of Treat All ART recommendations among adults and adolescents living with HIV, implementation of Treat All policy for pregnant and breastfeeding women living with HIV, national policy on routine viral load testing for monitoring… Read More
This Waste Management session covered updates to the checklist for assessments of viral load (VL) and early infant diagnosis (EID) testing laboratories and associated healthcare facilities. David Bressler, MS, CBSP (SM) NRM of the International Laboratory Branch, CDC, Division of Global HIV and TB presented to the audience about the checklist/tool and its ability to… Read More
Integrating testing using multiplex technologies at the appropriate level of care can lead to more efficient and cost-effective testing services and can help to simplify and streamline other systems, such as specimen referral, human resources, and quality assurance. Integration should be a priority for both those countries with currently operational multi-disease testing devices and those… Read More
In the May 2019 session, Dr Katrina Sleeman, Associate Service Fellow in the Viral Load/Early Infant Diagnosis Team at the CDC ILB introduced a draft of a viral load WM checklist tool that can be used as baseline audit of select country VL labs. The tool aims to assist in creating awareness of best practices… Read More
In collaboration with ASLM and the LabCoP community, the CDC International Laboratory Branch (ILB) presented an overview of the World Health Organization (WHO) Publication: ‘Safe Management of Wastes from Health-Care Activities’ during the second ECHO session dedicated to waste management. This document, developed by WHO in 2017, highlights the key aspects of safe healthcare waste… Read More